4-Methylmorpholine → (S)-N-((1S,2S)-1-((2R,4R)-1-(4-methoxybenzyl)-4-(allyloxy)pyrrolidin-2-yl)-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl)-2-((R)-3-acetamido-3-isobutyl-2-oxopyrrolidin-1-yl)-4-phenylbutanamide

반응식

[C:1]([NH:4][C@:5]1([CH2:23][CH:24]([CH3:26])[CH3:25])[CH2:9][CH2:8][N:7]([C@@H:10]([CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:11](O)=[O:12])[C:6]1=[O:22])(=[O:3])[CH3:2].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH3:51][O:52][C:53]1[CH:81]=[CH:80][C:56]([CH2:57][N:58]2[CH2:62][C@H:61]([O:63][CH2:64][CH:65]=[CH2:66])[CH2:60][C@@H:59]2[C@@H:67]([OH:79])[C@@H:68]([NH2:78])[CH2:69][C:70]2[CH:75]=[C:74]([F:76])[CH:73]=[C:72]([F:77])[CH:71]=2)=[CH:55][CH:54]=1.CN1CCOCC1>CN(C=O)C>[CH3:51][O:52][C:53]1[CH:81]=[CH:80][C:56]([CH2:57][N:58]2[CH2:62][C@H:61]([O:63][CH2:64][CH:65]=[CH2:66])[CH2:60][C@@H:59]2[C@@H:67]([OH:79])[C@@H:68]([NH:78][C:11](=[O:12])[C@@H:10]([N:7]2[CH2:8][CH2:9][C@:5]([NH:4][C:1](=[O:3])[CH3:2])([CH2:23][CH:24]([CH3:25])[CH3:26])[C:6]2=[O:22])[CH2:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:69][C:70]2[CH:71]=[C:72]([F:77])[CH:73]=[C:74]([F:76])[CH:75]=2)=[CH:55][CH:54]=1