Hydrochloric Acid → HCID 178514823, 화합물

HRID 133015

반응식

HRID 133015 반응식
C([Mg]Cl)(C)C.Br[C:7]1[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=1.C([O:17][B:18]([CH:24]=[CH2:25])OCCCC)CCC.Cl>C1COCC1.O>[N:9]1[CH:10]=[CH:11][CH:12]=[C:7]([CH:25]=[CH:24][BH:18][OH:17])[CH:8]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 122863-BromopyridineHCID 236543Dibutyl Vinylboronate (stabilized with Phenothiazine)HCID 178418918HCID 178418918, 화합물

생성물 1

HCID 178514823HCID 178514823, 화합물수율 78%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Isopropylmagnesium chloride (2.0 M in THF) (5.0 mL, 10 mmol) was added to a solution of 3-bromopyridine (1.60 g, 10.0 mmol) in THF (15 mL) under nitrogen atmosphere at room temperature and the mixture was stirred for 1 h. Vinylboronic acid dibutyl ester (3.4 mL) was added to the reaction dropwise and the mixture was stirred at room temperature for 18 h. Water was added and the pH was adjusted to 7 with 1 M hydrochloric acid. The mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried on anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the title compound (1.04 g, 78%).

후처리

  1. stirringthe mixture was stirred at room temperature for 18 h
  2. extractionThe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with brine
  4. dry with materialdried on anhydrous sodium sulfate
  5. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-f6c3229880604ca08b2c20172511e4fc
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390806B2

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