Acetic Anhydride → N,5-Dimethyl-1H-indol-2-amine dihydrochloride

HRID 133171

반응식

HRID 133171 반응식
[ClH:1].[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9]N)=[CH:5][CH:4]=1.[CH2:11]([N:13](CC)[CH2:14]C)[CH3:12].C(OC(=O)C)(=O)C>O.CCOCC>[ClH:1].[ClH:1].[CH3:14][NH:13][C:11]1[NH:9][C:6]2[C:7]([CH:12]=1)=[CH:8][C:3]([CH3:2])=[CH:4][CH:5]=2

참가 물질

6

반응물 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 125044-Methylphenylhydrazine monohydrochloride

생성물 1

HCID 57435942N,5-Dimethyl-1H-indol-2-amine dihydrochloride

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매2회

반응 조건

온도
0 °C

실험 절차

5 g of 1-(4-methylphenyl)hydrazine hydrochloride are dissolved in water and then triethylamine is added until the salt has been neutralized. Extraction is carried out with AcOEt and then the extract is evaporated to dryness. The precipitate formed is dissolved in 30 ml of ether and then a solution of 4.6 ml of acetic anhydride dissolved in 30 ml of ether is added dropwise. The mixture is stirred at 0° C. for 15 minutes and then the precipitate formed is filtered off to produce 3 g of the expected compound.

후처리

  1. extractionExtraction
  2. customthe extract is evaporated to dryness
  3. customThe precipitate formed
  4. additionis added dropwise
  5. customthe precipitate formed
  6. filtrationis filtered off

출처 및 근거

ORD 기록
ord-1a490015bf8a457fa8d33947b9f5e475
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390818B2

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