Acetic Anhydride → n'-(4-Methoxyphenyl)acetohydrazide

HRID 133172

반응식

HRID 133172 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[CH:5][CH:4]=1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>CCOCC>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH:10][C:11](=[O:13])[CH3:12])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 77023(4-Methoxyphenyl)hydrazine

생성물 1

HCID 236267n'-(4-Methoxyphenyl)acetohydrazide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

반응 조건

온도
0 °C

실험 절차

10 g of 4-methoxyphenylhydrazine hydrochloride are dissolved in water and then triethylamine is added until the salt has been neutralized. Extraction is carried out with AcOEt and then the extract is evaporated to dryness to produce 8 g of precipitate composed of 4-methoxyphenyl-hydrazine. This compound is dissolved in 30 ml of ether and then a solution of 13 ml of acetic anhydride dissolved in 30 ml of ether is added dropwise. The mixture is stirred at 0° C. for 15 minutes and then the white precipitate formed is filtered off to produce 7.4 g of the expected compound.

후처리

  1. additionis added dropwise
  2. customthe white precipitate formed
  3. filtrationis filtered off

출처 및 근거

ORD 기록
ord-69979d3d03d44e0f9ff2c69267276cbf
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390818B2

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