Phosphorus tribromide → 5-(Bromomethyl)-6-chloro-2H-1,3-benzodioxole

HRID 133184노트

반응식

HRID 133184 반응식
[CH2:1]1[O:5][C:4]2[CH:6]=[C:7]([Cl:12])[C:8]([CH2:10]O)=[CH:9][C:3]=2[O:2]1.P(Br)(Br)[Br:14]>C(OCC)C>[Br:14][CH2:10][C:8]1[C:7]([Cl:12])=[CH:6][C:4]2[O:5][CH2:1][O:2][C:3]=2[CH:9]=1

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 7015319(6-Chloro-1,3-benzodioxol-5-yl)methanol

생성물 1

HCID 191052995-(Bromomethyl)-6-chloro-2H-1,3-benzodioxole

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

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온도
0 °C

실험 절차

2.5 g of 6-chloropiperonyl alcohol are dissolved in 80 ml of ethyl ether. The solution is cooled to 0° C. and then 1.9 ml of PBr3 are added. The mixture is stirred at ambient temperature for 18 hours. It is poured onto ice and then extraction is carried out with AcOEt. The organic phase is washed with a saturated NaCl solution. 3.3 g of powder are obtained.

후처리

  1. additionIt is poured onto ice
  2. extractionextraction
  3. washThe organic phase is washed with a saturated NaCl solution

출처 및 근거

ORD 기록
ord-c986d68ab36c4f71a5a08261f372926c
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390818B2

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