Methanol → Methyl 3-Hydroxyphenylacetate

HRID 133185

반응식

HRID 133185 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH3:12]O>S(=O)(=O)(O)O>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 121223'-Hydroxyphenylacetic acid

생성물 1

HCID 39129Methyl 3-Hydroxyphenylacetate

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

10 g of 3-hydroxyphenylacetic acid are dissolved in 60 ml of methanol and 2.5 ml of sulphuric acid. The solution is heated at reflux for two hours. It is brought back to ambient temperature and the methanol is evaporated. The residue is taken up in a saturated K2CO3 solution. Extraction is carried out with AcOEt. The organic phase is dried over MgSO4, filtered and evaporated to dryness. 11.1 g of oil are obtained.

후처리

  1. temperatureThe solution is heated
  2. temperatureat reflux for two hours
  3. customis brought back to ambient temperature
  4. customthe methanol is evaporated
  5. extractionExtraction
  6. dry with materialThe organic phase is dried over MgSO4
  7. filtrationfiltered
  8. customevaporated to dryness

출처 및 근거

ORD 기록
ord-7422c6e426094c6b92808842d39c97dd
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390818B2

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