2-Pyrazinecarboxylic acid → N-(4-benzyloxy-3-fluorophenyl)pyrazinecarboxamide

HRID 13324노트

반응식

HRID 13324 반응식
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([OH:9])=O.Cl.CN(C)CCCN=C=NCC.[CH2:22]([O:29][C:30]1[CH:36]=[CH:35][C:33]([NH2:34])=[CH:32][C:31]=1[F:37])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>N1C=CC=CC=1>[CH2:22]([O:29][C:30]1[CH:36]=[CH:35][C:33]([NH:34][C:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)=[O:9])=[CH:32][C:31]=1[F:37])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

참가 물질

5

반응물 3

HCID 10472-Pyrazinecarboxylic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 219518923-Fluoro-4-phenylmethoxyaniline

생성물 1

HCID 23145734N-(4-benzyloxy-3-fluorophenyl)pyrazinecarboxamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2.59 g of pyrazine-2-carboxylic acid and 4.73 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide monohydrochloride were added to a pyridine (60 ml) solution of 4.13 g of 4-benzyloxy-3-fluoroaniline, and the reaction liquid was stirred overnight at room temperature. Pyridine was evaporated away under reduced pressure, and then water was added to it. The resulting deposit was taken out through filtration to obtain the entitled compound as a brown solid.

후처리

  1. customthe reaction liquid
  2. customPyridine was evaporated away under reduced pressure
  3. additionwater was added to it
  4. filtrationThe resulting deposit was taken out through filtration

출처 및 근거

ORD 기록
ord-4f8f248a00a74e1a95b45c2060380d81
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

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