Pyridine → Isobutyl 2-bromopropionate

HRID 133308

반응식

HRID 133308 반응식
[CH2:1]([OH:5])[CH:2]([CH3:4])[CH3:3].N1C=CC=CC=1.[Br:12][CH:13]([CH3:17])[C:14](Br)=[O:15]>C(OCC)C>[Br:12][CH:13]([CH3:17])[C:14]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[O:15]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6560IsobutanolHCID 79047Propanoyl bromide, 2-bromo-

생성물 1

HCID 522337Isobutyl 2-bromopropionate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a mixture of iso-butanol and 1.0 equivalent of pyridine in dry diethyl ether was added dropwise 1.3 equivalents of 2-bromopropionyl bromide at 0° C. After stirring at room temperature for 16 hours, the reaction was diluted with diethyl ether, washed with 1N HCl, water, aqueous NaHCO3, brine and dried over magnesium sulfate or sodium sulfate. Removal of the solvents at reduced pressure gave the title compound as a clear oil.

후처리

  1. washwashed with 1N HCl, water, aqueous NaHCO3, brine
  2. dry with materialdried over magnesium sulfate or sodium sulfate
  3. customRemoval of the solvents at reduced pressure

출처 및 근거

ORD 기록
ord-bf0296674c8a4d2b99889b4a6245a2a7
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390801B2

연결된 노트

불러오는 중…