홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Cesium carbonate → 5-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-trifluoromethyl-pyridin-3-yloxy)-1H-benzimidazole

HRID 13331
노트
인쇄 미리보기

반응식

HRID 13331 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]([F:11])([F:10])[F:9])=[N:6][CH:7]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[F:18][C:19]1[CH:41]=[CH:40][CH:39]=[CH:38][C:20]=1[O:21][C:22]1[C:36]([OH:37])=[CH:35][C:25]2[NH:26][C:27]([C:29]3[CH:34]=[N:33][CH:32]=[CH:31][N:30]=3)=[N:28][C:24]=2[CH:23]=1>[Cu]=O.CN1CCCC1=O>[F:18][C:19]1[CH:41]=[CH:40][CH:39]=[CH:38][C:20]=1[O:21][C:22]1[C:36]([O:37][C:2]2[CH:7]=[N:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=2)=[CH:35][C:25]2[NH:26][C:27]([C:29]3[CH:34]=[N:33][CH:32]=[CH:31][N:30]=3)=[N:28][C:24]=2[CH:23]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 10796Cesium carbonateHCID 27611975-Bromo-2-(trifluoromethyl)pyridineHCID 1356979845-(2-fluorophenoxy)-6-hydroxy-2-pyrazin-2-yl-1H-benzimidazole

생성물 1

HCID 231457785-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-trifluoromethyl-pyridin-3-yloxy)-1H-benzimidazole

시약·촉매·용매 2

HCID 14829Copper oxide촉매
HCID 13387
N-methyl-2-pyrrolidone
용매

반응 조건

온도
130 °C

실험 절차

16 mg of 5-bromo-2-trifluoromethyl-pyridine, 50 mg of cesium carbonate and 10 mg of copper(II) oxide were added to an N-methylpyrrolidinone (1 ml) solution of 21 mg of 5-(2-fluorophenoxy)-6-hydroxy-2-pyrazin-2-yl-1H-benzimidazole obtained in Example 251 (step 1), and the reaction liquid was stirred at 130° C. for 5 hours. The deposit was separated through filtration, and the solution was purified through reversed-phase middle-pressure liquid chromatography [ODS-AS-360-CC (by YMC), mobile phase: water-acetonitrile-0.1% trifluoroacetic acid]. The resulting fraction was diluted with ethyl acetate, washed with aqueous saturated sodium bicarbonate, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound as a brown solid.

후처리

  1. customthe reaction liquid
  2. customThe deposit was separated through filtration
  3. customthe solution was purified through reversed-phase middle-pressure liquid chromatography [ODS-AS-360-CC (by YMC), mobile phase: water-acetonitrile-0.1% trifluoroacetic acid]
  4. additionThe resulting fraction was diluted with ethyl acetate
  5. washwashed with aqueous saturated sodium bicarbonate
  6. dry with materialdried with anhydrous sodium sulfate
  7. customThe solvent was evaporated away under reduced pressure

출처 및 근거

ORD 기록
ord-a8cabb912c264e1fb37b38fd8adc589b
출처 데이터셋
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07728025B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트