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Methanol → 2-[4'-(2,8-Bis-trifluoromethyl-quinolin-4-yloxymethyl)-biphenyl-4-sulfonylamino]-3-methyl-butyric acid

HRID 133409
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HRID 133409 반응식
C[O:2][C:3](=[O:44])[CH:4]([NH:8][S:9]([C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([CH2:24][O:25][C:26]3[C:35]4[C:30](=[C:31]([C:36]([F:39])([F:38])[F:37])[CH:32]=[CH:33][CH:34]=4)[N:29]=[C:28]([C:40]([F:43])([F:42])[F:41])[CH:27]=3)=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)(=[O:11])=[O:10])[CH:5]([CH3:7])[CH3:6].CO.[OH-].[Na+]>C1COCC1>[F:43][C:40]([F:41])([F:42])[C:28]1[CH:27]=[C:26]([O:25][CH2:24][C:21]2[CH:22]=[CH:23][C:18]([C:15]3[CH:14]=[CH:13][C:12]([S:9]([NH:8][CH:4]([CH:5]([CH3:7])[CH3:6])[C:3]([OH:44])=[O:2])(=[O:11])=[O:10])=[CH:17][CH:16]=3)=[CH:19][CH:20]=2)[C:35]2[C:30](=[C:31]([C:36]([F:37])([F:38])[F:39])[CH:32]=[CH:33][CH:34]=2)[N:29]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 865986322-[4'-(2,8-Bis-trifluoromethyl-quinolin-4-yloxymethyl)-biphenyl-4-sulfonylamino]-3-methyl-butyric acid methyl ester

생성물 1

HCID 730444322-[4'-(2,8-Bis-trifluoromethyl-quinolin-4-yloxymethyl)-biphenyl-4-sulfonylamino]-3-methyl-butyric acid수율 46%

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

2-[4′-(2,8-Bis-trifluoromethyl-quinolin-4-yloxymethyl)-biphenyl-4-sulfonylamino]-3-methyl-butyric acid methyl ester (1.026 g, 1.6 mmol, 1 equiv.) was dissolved in THF (15 mL) and MeOH (6 mL) and 1N NaOH (17.6 mL, 11 equiv.) was added. The reaction was monitored by TLC. It was complete in 3 days. Solvent was removed by rotovap and the residue was dissolved in H2O. The mixture was then acidified to pH 3 with 1N HCl. The resulting precipitate was collected by filtration and washed with cold water and dried overnight. 460 mg of white solid was obtained in 46% yield.

후처리

  1. customSolvent was removed by rotovap
  2. dissolutionthe residue was dissolved in H2O
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed with cold water
  5. customdried overnight

출처 및 근거

ORD 기록
ord-647bea4566b847dd927c5d799e30f440
출처 데이터셋
uspto-grants-2008_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07390833B2

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