Acetic Acid → Ethyl 3-(4-aminophenyl)-2-cyanoacrylate
반응식
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[C:10]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])#[N:11].C(NCC)C.C(O)(=O)C>C(O)C>[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[C:12]([C:10]#[N:11])[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:4][CH:3]=1참가 물질
6
실험 절차
36 g (0.3 mol) of para-aminobenzaldehyde are suspended in 300 ml of ethanol. 33.9 g (0.3 mol) of ethyl cyanoacetate and a mixture of 0.375 ml of diethylamine and 1.125 ml of acetic acid, as catalyst, are added to the suspension. The reaction mixture is refluxed for 2 hours, left to cool and then crystallized. After separating out the crystals by filtration and drying, 53.9 g (83% yield) of ethyl 3-(4-aminophenyl)-2-cyanoacrylate are obtained in the form of orange-coloured crystals.
후처리
- additionas catalyst, are added to the suspension
- temperatureThe reaction mixture is refluxed for 2 hours
- waitleft
- temperatureto cool
- customcrystallized
- customAfter separating out the crystals by filtration
- customdrying
출처 및 근거
- ORD 기록
- ord-6fe060502bb841b5a49f1768c8a4f508
- 출처 데이터셋
- uspto-grants-2008_06
- 특허 번호
- US07390916B2
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