Water → n-(2-Fluoro-4-hydroxyphenyl)acetamide

HRID 133732

반응식

HRID 133732 반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][C:10]=1[F:16].O>C(O)(=O)C>[F:16][C:10]1[CH:11]=[C:12]([OH:15])[CH:13]=[CH:14][C:9]=1[NH:8][C:5](=[O:7])[CH3:6]

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 27359194-Amino-3-fluorophenol

생성물 1

HCID 190616n-(2-Fluoro-4-hydroxyphenyl)acetamide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Acetic anhydride (1.3 ml, 13.8 mmol) was added dropwise to a solution of 4-amino-3-fluorophenol (1.0 g, 7.9 mmol) in acetic acid (25 ml) at room temperature. The reaction mixture was stirred at room temperature for 2 h and water (2 ml) was added and the stirring was continued for 30 minutes at room temperature. The mixture was evaporated to dryness in vacuo. The yield of the crude product was 1.3 g (100%) and it was used without further purification.

후처리

  1. waitthe stirring was continued for 30 minutes at room temperature
  2. customThe mixture was evaporated to dryness in vacuo
  3. customwas used without further purification

출처 및 근거

ORD 기록
ord-87286c2ade0143448a517e8f0fd7426b
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390923B2

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