Hydrochloric Acid → 4-(3-Chloropropyl)phenol
반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10]O)=[CH:4][CH:3]=1.[ClH:12]>O>[Cl:12][CH2:10][CH2:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=1참가 물질
4
실험 절차
3-(4-Hydroxyphenyl)-1-propanol (0.97 g, 0.006374 mol) and concentrated HCl (20 ml) were heated at 100° C. for 14 h. After being cooled, the reaction mixture was poured into water and extracted with ethyl acetate. The extracts were washed with water, dried and concentrated in vacuo to give a raw product. Purification by flash chromatography (heptane/ethyl acetate 9:1) gave a pure product (0.98 g, 90%).
후처리
- temperatureAfter being cooled
- extractionextracted with ethyl acetate
- washThe extracts were washed with water
- customdried
- concentrationconcentrated in vacuo
- customto give a raw product
- customPurification by flash chromatography (heptane/ethyl acetate 9:1)
출처 및 근거
- ORD 기록
- ord-5ddef234d35e48a58ec24166d96c46f4
- 출처 데이터셋
- uspto-grants-2008_06
- 특허 번호
- US07390923B2
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