Methanamine, N-methoxy-, hydrochloride (1:1) → 2-fluoro-N-methoxy-N-methylbenzamide

HRID 13418노트

반응식

HRID 13418 반응식
Cl.[CH3:2][O:3][NH:4][CH3:5].Cl.C(N=C=NCCCN(C)C)C.[F:18][C:19]1[CH:27]=[C:26]([N+]([O-])=O)[CH:25]=[CH:24][C:20]=1[C:21]([OH:23])=O>N1C=CC=CC=1>[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([N:4]([O:3][CH3:2])[CH3:5])=[O:23]

참가 물질

5

반응물 3

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 3026792-Fluoro-4-nitrobenzoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

생성물 1

HCID 183575562-fluoro-N-methoxy-N-methylbenzamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

5.79 g of N-methoxy-N-methylamine hydrochloride and 12.4 g of 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide hydrochloride were added to a pyridine (80 ml) suspension of 10 g of 2-fluoro-4-nitrobenzoic acid, and the reaction liquid was stirred overnight at room temperature. Pyridine was evaporated away under reduced pressure, and water was added to it. The resulting deposit was taken out through filtration, washed with water, and dried to obtain the entitled compound as a pale yellow solid.

후처리

  1. customthe reaction liquid
  2. customPyridine was evaporated away under reduced pressure, and water
  3. additionwas added to it
  4. filtrationThe resulting deposit was taken out through filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-76d5f9db0bc242af8f1bbe578660f790
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

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