p-Fluoronitrobenzene → 1-Ethyl-4-(4-nitrophenyl)piperazine

HRID 13478

반응식

HRID 13478 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH2:11]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH3:12].C(N(CC)C(C)C)(C)C>CN(C)C=O>[CH2:11]([N:13]1[CH2:18][CH2:17][N:16]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)[CH2:15][CH2:14]1)[CH3:12]

참가 물질

5

반응물 3

HCID 9590p-FluoronitrobenzeneHCID 791961-EthylpiperazineHCID 81531Diisopropylethylamine

생성물 1

HCID 28575491-Ethyl-4-(4-nitrophenyl)piperazine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

To 4-fluoro-1-nitrobenzene (1 eq) in N,N-dimethylformamide was added Ethyl piperazine (2 eq) and N,N-diisopropylethyl amine (2 eq) and heated at 80° C. for 16 h. Concentrated the resultant mixture and partitioned between ethyl acetate and water. The organic layer was then washed with brine and dried with sodium sulfate and concentrated. Passed through a plug of silica to yield 4-Ethyl-1-(4-nitrophenyl)piperazine. MS: MH+=235.

후처리

  1. concentrationConcentrated the resultant mixture
  2. custompartitioned between ethyl acetate and water
  3. washThe organic layer was then washed with brine
  4. dry with materialdried with sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2510e61220fa4f0aa0020614d8a05773
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728010B2

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