Morpholine → 4-[2-(4-Nitrophenyl)ethyl]morpholine

HRID 13480

반응식

HRID 13480 반응식
Br[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][CH:5]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>O1CCCC1>[N+:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)=[CH:5][CH:6]=1)([O-:12])=[O:11]

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 792664-Nitrophenethyl bromide

생성물 1

HCID 27974734-[2-(4-Nitrophenyl)ethyl]morpholine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 4-(2-bromoethyl)-1-nitrobenzene (1 eq) in tetrahydrofuran was added morpholine (3 eq) and stir for 16 h at ambient temperature. Concentrating and passing through a plug of silica gave 4-[2-(4-nitrophenyl)ethylmorpholine. MS: MH+=236.

후처리

  1. concentrationConcentrating

출처 및 근거

ORD 기록
ord-6a95f2b711a1461a8fd21c53214e6a68
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728010B2

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