Water → [1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine

HRID 1348564

반응식

HRID 1348564 반응식
[CH3:1][N:2]([CH3:18])[CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1.[C:19](C1NC=CN=1)(C1NC=CN=1)=[S:20].O>CN(C=O)C>[N:15]([C:12]1[CH:13]=[CH:14][C:9]([N:6]2[CH2:7][CH2:8][CH:3]([N:2]([CH3:18])[CH3:1])[CH2:4][CH2:5]2)=[CH:10][CH:11]=1)=[C:19]=[S:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 11086151N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amineHCID 11412697Thiocarbonyl diimidazole

생성물 1

HCID 21091577[1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine (Example 2, 1.1 g, 5.0 mmol) was dissolved in DMF (5 mL). To the stirred solution, thiocarbonyl diimidazole (Aldrich, 1.18 g, 90%, 6 mmol) was added and the solution was stirred at room temperature for 80 minutes. The mixture was poured into water and extracted with diethyl ether. The extract was dried with sodium sulfate and concentrated to give a pale yellow solid. 1.12 g, 85%. MS (m+H)+: 262.

후처리

  1. extractionextracted with diethyl ether
  2. dry with materialThe extract was dried with sodium sulfate
  3. concentrationconcentrated
  4. customto give a pale yellow solid

출처 및 근거

ORD 기록
ord-96af6633f0ff44f3afb9eaf504ffa333
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07211576B2

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