홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Methyl iodide → 4-({2-[(4-bromophenyl)amino]-1-methyl-1H-1,3-benzodiazol-6-yl}oxy)-N-methylpyridine-2-carboxamide

HRID 13486
노트
인쇄 미리보기

반응식

HRID 13486 반응식
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:12]=[CH:11][N:10]=[C:9]([C:13]([NH:15][CH3:16])=[O:14])[CH:8]=2)=[CH:4][C:3]=1[NH:19][CH3:20].[Br:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]=[C:29]=S)=[CH:24][CH:23]=1.IC>CO>[Br:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]2[N:19]([CH3:20])[C:3]3[CH:4]=[C:5]([O:6][C:7]4[CH:12]=[CH:11][N:10]=[C:9]([C:13]([NH:15][CH3:16])=[O:14])[CH:8]=4)[CH:17]=[CH:18][C:2]=3[N:1]=2)=[CH:24][CH:23]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 161334-Bromophenyl isothiocyanateHCID 58385469{4-[4-Amino-3-(methylamino)phenoxy](2-pyridyl)}-n-methylcarboxamide

생성물 1

HCID 220409784-({2-[(4-bromophenyl)amino]-1-methyl-1H-1,3-benzodiazol-6-yl}oxy)-N-methylpyridine-2-carboxamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

A solution of the {4-[4-amino-3-(methylamino)phenoxy](2-pyridyl)}-N-methylcarboxamide (1 eq) in methanol was treated with 4-bromophenylisothiocyanate (1 eq) and stirred at 60° C. for 2 hours. The reaction mixture was cooled down to room temperature and iodomethane (1 eq) was added and stirred overnight at 60° C. The reaction was concentrated and preparative chromatography gave (4-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-6-yloxy)-(2-pyridyl)-N-methylcarboxamide. MS: MH+=452.

후처리

  1. temperatureThe reaction mixture was cooled down to room temperature
  2. stirringstirred overnight at 60° C
  3. concentrationThe reaction was concentrated

출처 및 근거

ORD 기록
ord-d9b825c1331b431db4f94a518ed820f5
출처 데이터셋
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07728010B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트