Lithium Hydroxide → HCID 21091408, 화합물

HRID 1348636노트

반응식

HRID 1348636 반응식
C([O:3][C:4](=[O:19])[C:5]([OH:18])([CH3:17])[C:6]([NH:8][CH2:9][C:10]([F:16])([F:15])[C:11]([F:14])([F:13])[F:12])=[O:7])C.[OH-].[Li+]>O1CCCC1.O>[OH:18][C:5]([CH3:17])([C:6]([NH:8][CH2:9][C:10]([F:15])([F:16])[C:11]([F:12])([F:14])[F:13])=[O:7])[C:4]([OH:19])=[O:3]

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 86605288HCID 86605288, 화합물

생성물 1

HCID 21091408HCID 21091408, 화합물수율 94%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2.91 g (9.93 mmol) 2-hydroxy-2-methyl-N-(2,2,3,3,3-pentafluoro-propyl)-malonamic acid ethyl ester in 50 ml of tetrahydrofurane were added 0.42 g (9,92 mmol) of lithium hydroxide in 20 ml of water and the mixture was stirred overnight at room temperature. After concentration in vacuo water (50 ml) was added and the mixture was acidified to pH 1. Extraction with ethylacetate gave 2.46 g (94%) of the title compound as a solid, MS m/e (%): 263.9 (M−H, 100).

후처리

  1. concentrationAfter concentration in vacuo water (50 ml)
  2. additionwas added
  3. extractionExtraction with ethylacetate

출처 및 근거

ORD 기록
ord-e6ba9f4284eb45ec9709f5dcaa2179e5
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07211573B2

반응 노트

불러오는 중…