Ethanol → HCID 69141826, 화합물

HRID 1348949노트

반응식

HRID 1348949 반응식
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]([C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[CH2:12][C:13]([OH:15])=[O:14])[CH:9]=2)[CH2:4][CH2:3][NH:2]1.C(=O)(O)[O-].[Na+].[CH2:27](O)[CH3:28]>Cl>[CH2:27]([O:14][C:13](=[O:15])[CH2:12][CH:11]([C:8]1[CH:9]=[C:10]2[C:5]([CH2:4][CH2:3][NH:2][CH2:1]2)=[CH:6][CH:7]=1)[C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)[CH3:28]

참가 물질

5

반응물 3

HCID 702EthanolHCID 516892Sodium BicarbonateHCID 210924353-(1,2,3,4-Tetrahydro-isoquinolin-7-yl)-3-(pyrid-4-yl)-propionic acid

생성물 1

HCID 69141826HCID 69141826, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid촉매

실험 절차

A solution of 3-(1,2,3,4-tetrahydro-isoquinolin-7-yl)-3-(pyrid-4-yl)-propionic acid, enantiomer A {Reference Example 18(a)} in ethanol (50 mL) was treated with concentrated hydrochloric acid (two drops) and then heated at reflux temperature, under nitrogen, for 8 hours. The pH of the reaction mixture was adjusted to ˜5 by dropwise addition of sodium bicarbonate solution (5%) and this mixture was then evaporated to give the title compound which was used without further purification.

후처리

  1. temperatureheated
  2. temperatureat reflux temperature
  3. customthis mixture was then evaporated

출처 및 근거

ORD 기록
ord-824b961eb6544d678e784cde14d7b3a3
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07211586B2

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