2-Bromobenzoyl chloride → (2-Bromophenyl)(4-methylpiperazin-1-yl)methanone

HRID 1350043노트

반응식

HRID 1350043 반응식
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:15]1[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]1)=[O:5]

참가 물질

4

반응물 2

HCID 235422-Bromobenzoyl chlorideHCID 531671-Methylpiperazine

생성물 1

HCID 668767(2-Bromophenyl)(4-methylpiperazin-1-yl)methanone수율 78.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of 2-bromobenzoyl chloride (2 g, 9 mmol) in toluene (30 mL) was added N-methylpiperazine (2 mL, 18 mmol, 2 equiv.). The resulting mixture was stirred overnight. The precipitate was filtered and the filtrate was concentrated under reduced pressure. The residue was taken into dichloromethane, washed with water. The organic layer was concentrated under reduced pressure to give 2 g (77% yield) of intermediate 10.

후처리

  1. filtrationThe precipitate was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. washwashed with water
  4. concentrationThe organic layer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a0aff40fd8cd48d497cc85e959dfde82
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214676B2

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