Hydrochloric Acid → N-{4-[(1R)-1-aminoethyl]-2-methylphenyl)methanesulfonamide hydrochloride

HRID 1350845

반응식

HRID 1350845 반응식
C([S@]([NH:7][C@@H:8]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:12]([CH3:21])[CH:11]=1)[CH3:9])=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[NH2:7][C@@H:8]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:12]([CH3:21])[CH:11]=1)[CH3:9]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58640404N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-methylphenyl]methanesulfonamide

생성물 1

HCID 21097519N-{4-[(1R)-1-aminoethyl]-2-methylphenyl)methanesulfonamide hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To N-[4-((1R)-1-{[(R)-tert-butylsulfinyl]amino}ethyl)-2-methylphenyl]methanesulfonamide (530 mg,1.60 mmol) was added 10% methanolic hydrogen chloride (5.0 ml) and dioxane (5.0 ml). The solution was stirred at ambient temperature for 30 minutes and then concentrated under reduced pressure. Diethyl ether was added to precipitate amine hydrochloride. The precipitate was then filtered, washed with diethyl ether and collected to furnish 450 mg (quant.) of the title compound as a white solid.

후처리

  1. concentrationconcentrated under reduced pressure
  2. additionDiethyl ether was added
  3. customto precipitate amine hydrochloride
  4. filtrationThe precipitate was then filtered
  5. washwashed with diethyl ether
  6. customcollected

출처 및 근거

ORD 기록
ord-8b544fffb3e84e5e96885c6b82505aac
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214824B2

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