HCID 58640415, 화합물 → HCID 21097450, 화합물

HRID 1350855노트

반응식

HRID 1350855 반응식
[CH3:1][C:2]1([CH3:18])[C:10]2[C:5](=[CH:6][C:7]([O:11][CH2:12][C:13]([O:15]CC)=[O:14])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1>C(O)C.[OH-].[Na+]>[CH3:1][C:2]1([CH3:18])[C:10]2[C:5](=[CH:6][C:7]([O:11][CH2:12][C:13]([OH:15])=[O:14])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

참가 물질

4

반응물 1

HCID 58640415HCID 58640415, 화합물

생성물 1

HCID 21097450HCID 21097450, 화합물수율 89%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

A mixture of ethyl [(1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)oxy]acetate (1.14 g, 4.58 mmol) in ethanol (20 ml) and 2M sodium hydroxide aqueous solution (4 ml) was refluxed for 2 hours. After cooling to ambient temperature, the solvent was evaporated in vacuo and the aqueous solution was acidified to pH 2 with 2M hydrochloride aqueous solution with ice-cooling. The precipitate solid was collected and dried in vacuo to give 894 mg (89% yield) of the title compound as a pale gray solid.

후처리

  1. temperaturewas refluxed for 2 hours
  2. customthe solvent was evaporated in vacuo
  3. temperaturecooling
  4. customThe precipitate solid was collected
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-6bc3efdb0cb64060858432a608c8d255
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214824B2

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