Dimethylformamide → Dichlorobenzylidenamine

HRID 1350911

반응식

HRID 1350911 반응식
Cl.[Cl:2]CCC(N)(C)C.[Cl:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14](Cl)[C:11]=1C=O.C[N:20]([CH3:23])C=O>C1(C)C=CC=CC=1.C(C(OC(CC)(CC)C)(CC)C)C.O1CCCC1.CS(C)=O.C(Cl)Cl>[Cl:9][C:10]1[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=1[C:23]([Cl:2])=[NH:20]

참가 물질

9

반응물 3

HCID 6228DimethylformamideHCID 67372,6-DichlorobenzaldehydeHCID 210945474-Chloro-2-methylbutan-2-amine hydrochloride

생성물 1

HCID 131726441Dichlorobenzylidenamine

시약·촉매·용매 5

HCID 679Dimethyl Sulfoxide용매HCID 1140Toluene용매HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매HCID 12430074Diethylethylether용매

실험 절차

The base is liberated from about 80–90, preferably 84.0 mmol of 3-chloro-1,1-dimethylpropylamine-hydrochloride by known methods. The free base is dissolved in about 50 mL of a solvent, preferably toluene, diethylethylether, tetrahydrofuran, dimethylsulphoxide, dimethylformamide or methylene chloride and about 60 to 100 mmol, preferably 80.0 mmol of 2,6-dichlorobenzaldehyde are added at ambient temperature, with stirring. The reaction mixture is stirred for 5 to 20 h, preferably for 15 h at ambient temperature, dried again and the solvent is removed. The corresponding dichlorobenzylidenamine of compound (III) is obtained.

후처리

  1. additionare added at ambient temperature
  2. stirringThe reaction mixture is stirred for 5 to 20 h, preferably for 15 h at ambient temperature
  3. customdried again
  4. customthe solvent is removed

출처 및 근거

ORD 기록
ord-6af98bf814c24801a9689cef8d7e3e26
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07214698B2

연결된 노트

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