p-Fluorophenethylamine → HCID 21098561, 화합물

HRID 1351256노트

반응식

HRID 1351256 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1.[CH:11]([N:14](CC)C(C)C)(C)[CH3:12].BrCC#N>C(#N)C.C(OCC)(=O)C>[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH:8][CH2:12][C:11]#[N:14])=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 4653p-FluorophenethylamineHCID 11534BromoacetonitrileHCID 81531Diisopropylethylamine

생성물 1

HCID 21098561HCID 21098561, 화합물

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 4-fluorophenethylamine (1.4 g) in acetonitrile (20 mL) was added dropwise N,N-diisopropylethylamine (2.6 mL) and bromoacetonitrile (0.84 mL). After stirring at room temperature for 50 minutes, the solution was diluted with ethyl acetate, the solution was washed with water, then with saturated sodium chloride water. After drying with anhydrous sodium sulfate, the solvent was removed by evaporation to provide the title compound (2.12 g) as a yellow oily substance.

후처리

  1. washthe solution was washed with water
  2. dry with materialAfter drying with anhydrous sodium sulfate
  3. customthe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-4a0da7085a9d4a9db625dd90774ae72a
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07217723B2

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