Acetone → [2-(4-Fluorophenyl)ethyl](propan-2-yl)amine

HRID 1351257노트

반응식

HRID 1351257 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1.[CH3:11][C:12]([CH3:14])=O.CO.C([BH3-])#N.[Na+]>C(O)(=O)C.C(OCC)(=O)C.O>[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH:8][CH:12]([CH3:14])[CH3:11])=[CH:4][CH:3]=1

참가 물질

8

반응물 4

HCID 180AcetoneHCID 887MethanolHCID 4653p-FluorophenethylamineHCID 5003444Sodium cyanoborohydride

생성물 1

HCID 21098562[2-(4-Fluorophenyl)ethyl](propan-2-yl)amine

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 4-fluorophenethylamine (1.4 g) in acetic acid (10 mL) was added dropwise acetone (0.82 mL) and methanol (20 mL). After sodium cyano-borohydride (0.64 g) was added, and the solution was stirred at room temperature for 2.5 hours. After adding water and diluting with ethyl acetate, the solution was washed with water and saturated sodium chloride water. After drying with anhydrous sodium sulfate, the residue that was obtained upon removing the solvent by evaporation was purified by NAM silica gel column chromatography (hexane/ethyl acetate), and the title compound (0.62 g) was obtained as colorless solids.

후처리

  1. washthe solution was washed with water and saturated sodium chloride water
  2. dry with materialAfter drying with anhydrous sodium sulfate
  3. customthe residue that was obtained
  4. customupon removing the solvent
  5. customby evaporation
  6. customwas purified by NAM silica gel column chromatography (hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-7b3d68e78fb04411aa64ef3012cb2c39
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07217723B2

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