Water → HCID 21098653, 화합물

HRID 1351291노트

반응식

HRID 1351291 반응식
[CH3:1][NH:2][S:3]([C:6]1[S:7][C:8]([Br:11])=[CH:9][CH:10]=1)(=[O:5])=[O:4].[H-].[Na+].Br[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=1)=[O:17].O>O1CCCC1.C(OCC)(=O)C>[F:24][C:21]1[CH:22]=[CH:23][C:18]([C:16](=[O:17])[CH2:15][N:2]([CH3:1])[S:3]([C:6]2[S:7][C:8]([Br:11])=[CH:9][CH:10]=2)(=[O:4])=[O:5])=[CH:19][CH:20]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 24758Sodium hydrideHCID 967492-Bromo-1-(4-fluorophenyl)ethan-1-oneHCID 15203645-BroMo-thiophene-2-sulfonic acid M ethylaMide

생성물 1

HCID 21098653HCID 21098653, 화합물수율 49.8%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 5-bromothiophene-2-sulfonic acid methyl-amide (608 mg) in tetrahydrofuran (5 mL) was added 60% sodium hydride (115 mg). After stirring for 20 minutes, 2-bromo-1-(4-fluorophenyl)ethanone (630 mg) was added. After adding water and ethyl acetate, and washing the organic layer with saturated sodium chloride water, this solution was dried with anhydrous sodium sulfate. The residue that was obtained upon removing the solvent by evaporation was purified by silica gel column chromatography (hexane/ethyl acetate) and the title compound (464 mg) was obtained as a yellow oily substance.

후처리

  1. washwashing the organic layer with saturated sodium chloride water
  2. dry with materialthis solution was dried with anhydrous sodium sulfate
  3. customThe residue that was obtained
  4. customupon removing the solvent
  5. customby evaporation
  6. customwas purified by silica gel column chromatography (hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-2bb6a6d508844cbfbfc84d6e1733606f
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07217723B2

반응 노트

불러오는 중…