Acetic Anhydride → 1-Acetyl-3-azetidinecarboxylic acid

반응식

[NH:1]1[CH2:4][CH:3]([C:5]([OH:7])=[O:6])[CH2:2]1.[C:8](OC(=O)C)(=[O:10])[CH3:9]>>[C:8]([N:1]1[CH2:4][CH:3]([C:5]([OH:7])=[O:6])[CH2:2]1)(=[O:10])[CH3:9]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 931923-azetidinecarboxylic Acid

생성물 1

HCID 133743571-Acetyl-3-azetidinecarboxylic acid

실험 절차

3-Azetidine carboxylic acid (2.25 g, 22.2 mmol) and acetic anhydride (80 ml) were heated gently until all of the acid had dissolved. The reaction was stirred at room temperature for 18 hours and then the acetic anhydride was removed under reduced pressure. Water was added and evaporated under reduced pressure. The residue was dissolved in hot ethyl acetate and filtered whilst hot and the filtrate was evaporated under reduced pressure to afford the title compound as a white solid, 1.54 g.

후처리

dissolutionhad dissolved
customthe acetic anhydride was removed under reduced pressure
additionWater was added
customevaporated under reduced pressure
dissolutionThe residue was dissolved in hot ethyl acetate
filtrationfiltered whilst hot and the filtrate
customwas evaporated under reduced pressure

출처 및 근거

ORD 기록: ord-d9969137f74d4fa0925b8ccaec78fd90
출처 데이터셋: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07217714B1

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