Hydrochloric Acid → HCID 69458120, 화합물

HRID 1351964노트

반응식

HRID 1351964 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:8]2[O:12][C:11](=[O:13])[N:10]([C@H:14]([CH3:33])[CH2:15][C:16]3[C:24]4[C:19](=[C:20]([NH:25]C(=O)OC(C)(C)C)[CH:21]=[CH:22][CH:23]=4)[NH:18][CH:17]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Cl>CO>[NH2:25][C:20]1[CH:21]=[CH:22][CH:23]=[C:24]2[C:19]=1[NH:18][CH:17]=[C:16]2[CH2:15][C@H:14]([N:10]1[CH2:9][C@@H:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[O:12][C:11]1=[O:13])[CH3:33]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 69458797HCID 69458797, 화합물

생성물 1

HCID 69458120HCID 69458120, 화합물수율 90.4%

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of tert-butyl 3-((2R)-2-((5R)-5-(3-chlorophenyl)-2-oxo-1,3-oxazolidin-3-yl)propyl)-1H-indol-7-ylcarbamate (419.2 mg, 0.894 mmol) in methanol (2 mL) is added a 10% solution of hydrochloric acid in methanol (10 mL) under nitrogen atmosphere, and the mixture is stirred at room temperature for 21 hours. The solvent is evaporated, and the residue is separated into a saturated ammonia solution in chloroform and water, and the organic layer is washed with a saturated brine, and dried over anhydrous sodium sulfate. The solvent is evaporated, and the obtained crude product is purified by silica gel column chromatography (a saturated ammonia solution in chloroform-methanol=1:0 20:1) to give the title compound (299 mg, 90%).

후처리

  1. customThe solvent is evaporated
  2. customthe residue is separated into a saturated ammonia solution in chloroform and water
  3. washthe organic layer is washed with a saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent is evaporated
  6. customthe obtained crude product
  7. customis purified by silica gel column chromatography (a saturated ammonia solution in chloroform-methanol=1:0 20:1)

출처 및 근거

ORD 기록
ord-6eebcda1781a430484f4a3a5903af440
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07217724B2

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