(+-)-2-Butanol → 2-Sec-butoxy-5-methanesulfonyl-benzoic acid

반응식

Cl[C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:15][CH:16]([OH:19])[CH2:17][CH3:18]>>[CH:16]([O:19][C:2]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])([CH2:17][CH3:18])[CH3:15]

참가 물질

반응물 2

HCID 6568(+-)-2-Butanol

HCID 23291322-Chloro-5-(methylsulphonyl)benzoic acid

생성물 1

HCID 211002582-Sec-butoxy-5-methanesulfonyl-benzoic acid

실험 절차

Prepared in analogy to Example A1 (b) from 2-chloro-5-methanesulfonyl-benzoic acid (Example A1(a)) and rac-butan-2-ol. The crude material was purified by preparative HPLC to yield the title compound as a white solid. MS (m/e): 271.4 ([M−H]−, 100%).

후처리

customThe crude material was purified by preparative HPLC

출처 및 근거

ORD 기록: ord-6ec63ae73e8945939112276519955628
출처 데이터셋: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07220744B2

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