Hydrochloric Acid → 1-[5-(Propane-2-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride

반응식

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]([S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])=[CH:17][N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>>[ClH:25].[CH3:24][CH:22]([S:19]([C:16]1[S:15][C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[N:18][CH:17]=1)(=[O:20])=[O:21])[CH3:23]

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 684062884-[5-(Propane-2-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 675498161-[5-(Propane-2-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride수율 97%

실험 절차

Prepared in analogy to example 4 (d) from 4-[5-(propane-2-sulfonyl)-thiazol-2-yl]-piperazine-1-carboxylic acid tert-butyl ester and hydrogen chloride solution. The crude material was purified by recrystallisation from ether to afford the title compound as a white crystalline solid (yield 97%). MS (m/e): 276.4 (M+H+, 100%).

후처리

customThe crude material was purified by recrystallisation from ether

출처 및 근거

ORD 기록: ord-52f72b96263d44c1ad5b18fe11fffb50
출처 데이터셋: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07220744B2

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