Aniline → N-phenylquinolin-4-amine
반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>[OH-].[Na+]>[C:13]1([NH:12][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][CH:3]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1참가 물질
4
반응 조건
- 온도
- 150 °C
실험 절차
A mixture of 4-chloroquinoline (10 g) and aniline (11.4 g) was warmed to 150° C. for 30 min. A solution of sodium hydroxide 1 N (200 ml) was added. After extraction with ethyl acetate (1 L), the organic layer was separated and dried over sodium sulfate. The solvent was removed to afford an amorphous materiel, which was crystallized in cyclohexane. Phenyl-quinolin-4-yl-amine (13.7 g) was obtained after filtration.
후처리
- extractionAfter extraction with ethyl acetate (1 L)
- customthe organic layer was separated
- dry with materialdried over sodium sulfate
- customThe solvent was removed
- customto afford an amorphous materiel, which
- customwas crystallized in cyclohexane
출처 및 근거
- ORD 기록
- ord-bc16656bbf82477d8617d02915ddd810
- 출처 데이터셋
- uspto-grants-2007_05
- 특허 번호
- US07220760B2
반응 노트
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