4-Chloroquinoline → 681828-34-2

HRID 1352504노트

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HRID 1352504 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH:12]1([NH2:15])[CH2:14][CH2:13]1>[OH-].[Na+]>[CH:12]1([NH:15][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][CH:3]=2)[CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 691404-ChloroquinolineHCID 69828Cyclopropylamine

생성물 1

HCID 22935736681828-34-2수율 42.2%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

반응 조건

온도
180 °C

실험 절차

A mixture of 4-chloroquinoline (13.9 g) and cyclopropyl amine (9.7 g) was heated at 180° C. under stirring for 16 hours. After cooling, a solution of sodium hydroxide 1N (200 ml) was added. After extraction with dichloromethane (200 ml), the organic layer was separated and dried over sodium sulfate. The solvent was removed under reduce pressure to afford an oil, which was crystallized in acetonitrile (50 ml). Cyclopropyl-quinolin-4-yl-amine (6.6 g; 42% yield) was obtained after filtration.

후처리

  1. temperatureAfter cooling
  2. extractionAfter extraction with dichloromethane (200 ml)
  3. customthe organic layer was separated
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was removed
  6. customto afford an oil, which
  7. customwas crystallized in acetonitrile (50 ml)

출처 및 근거

ORD 기록
ord-101b4c391dc143f3a370737c41a1a6b8
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220760B2

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