Ethanol → 5,6-Dichloro-2-(4-carboxy-2-methoxyphenyl)benzimidazole

HRID 1352654노트

반응식

HRID 1352654 반응식
[Cl:1][C:2]1[C:20]([Cl:21])=[CH:19][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13]C(C#N)=[CH:11][C:10]=3[O:17][CH3:18])[NH:8][C:4]=2[CH:3]=1.[OH-:22].[Na+].[CH2:24]([OH:26])[CH3:25]>>[Cl:1][C:2]1[C:20]([Cl:21])=[CH:19][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:25]([C:24]([OH:22])=[O:26])=[CH:11][C:10]=3[O:17][CH3:18])[NH:8][C:4]=2[CH:3]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 211011705,6-Dichloro-2-(4-cyano-2-methoxyphenyl)benzimidazole

생성물 1

HCID 211011665,6-Dichloro-2-(4-carboxy-2-methoxyphenyl)benzimidazole수율 46%

실험 절차

A solution of 5,6-dichloro-2-(4-cyano-2-methoxyphenyl)benzimidazole, prepared as described in Preparation 5, in ethanol (50 ml) and 2N NaOH (15 ml) was refluxed for 16 h. Solvent was removed under reduced pressure and the residue was acidified with 37% HCl (10 ml), stirred for 1 h. The solid was filtered, washed with water (50 ml), dried at 50° C. under vacuum to give 0.92 g of the title compound (yield 46%), mp>250° C.

후처리

  1. customSolvent was removed under reduced pressure
  2. filtrationThe solid was filtered
  3. washwashed with water (50 ml)
  4. customdried at 50° C. under vacuum

출처 및 근거

ORD 기록
ord-3445a8b6f87740ee933c94b4d448fb7d
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220769B2

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