Sodium Hydroxide → 4-(5,6-dichloro-1H-benzimidazol-2-yl)benzoic acid

HRID 1352656노트

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HRID 1352656 반응식
[Cl:1][C:2]1[C:20]([Cl:21])=[CH:19][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([O:17]C)=[O:16])=[CH:11][CH:10]=3)[NH:8][C:4]=2[CH:3]=1.[OH-].[Na+]>C1COCC1>[Cl:21][C:20]1[C:2]([Cl:1])=[CH:3][C:4]2[N:8]=[C:7]([C:9]3[CH:10]=[CH:11][C:12]([C:15]([OH:17])=[O:16])=[CH:13][CH:14]=3)[NH:6][C:5]=2[CH:19]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 21101171HCID 21101171, 화합물

생성물 1

HCID 40731194-(5,6-dichloro-1H-benzimidazol-2-yl)benzoic acid수율 91.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

A mixture of 5,6-dichloro-2-(4-methoxycarbonylphenyl)benzimidazole (2.4 g, 7.47 mmol), prepared as described in Preparation 7, 20% NaOH (7.5 ml, 37.5 mmol) in THF (25 ml) was heated at 50° C. for 1 h. After cooling at room temperature, solvent was removed under reduced pressure and pH was adjusted to 5 with acetic acid. The solid that was precipitated was filtered and dried at 50° C. to give 2.1 g of the title compound (yield 91.8%) as a brown solid, mp>250° C.

후처리

  1. customprepared
  2. temperatureAfter cooling at room temperature
  3. customsolvent was removed under reduced pressure and pH
  4. customThe solid that was precipitated
  5. filtrationwas filtered
  6. customdried at 50° C.

출처 및 근거

ORD 기록
ord-7223f598e4994bda884043da906bdf42
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220769B2

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