Thiophosgene → 3-Phenoxyphenylisothiocyanate

HRID 13530

반응식

HRID 13530 반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH:12]=[CH:13][CH:14]=1)[NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](Cl)(Cl)=[S:16].CCCCCC.CCOC(C)=O>CC(C)=O>[O:1]([C:8]1[CH:9]=[C:10]([N:11]=[C:15]=[S:16])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 10040ThiophosgeneHCID 771353-PhenoxyanilineHCID 21226206Ethyl acetate hexane

생성물 1

HCID 220412813-Phenoxyphenylisothiocyanate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a stirring solution of 3-phenoxyaniline (185 mg, 1.0 mmol) in acetone (4.0 mL) at 0° C. was added thiophosgene (0.23 mL, 3.0 mmol) and the resulting reaction maintained for 30 min. The reaction determined complete by TLC (4:1 hexane/EtOAc). The reaction was concentrated, azeotroped with toluene and taken on without further purification.

후처리

  1. customthe resulting reaction
  2. temperaturemaintained for 30 min
  3. concentrationThe reaction was concentrated
  4. customazeotroped with toluene
  5. customtaken on without further purification

출처 및 근거

ORD 기록
ord-b272333b6f17485f927833b273755ad7
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728010B2

연결된 노트

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