Thiophosgene → 3-Phenoxyphenylisothiocyanate
반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH:12]=[CH:13][CH:14]=1)[NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](Cl)(Cl)=[S:16].CCCCCC.CCOC(C)=O>CC(C)=O>[O:1]([C:8]1[CH:9]=[C:10]([N:11]=[C:15]=[S:16])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
5
실험 절차
To a stirring solution of 3-phenoxyaniline (185 mg, 1.0 mmol) in acetone (4.0 mL) at 0° C. was added thiophosgene (0.23 mL, 3.0 mmol) and the resulting reaction maintained for 30 min. The reaction determined complete by TLC (4:1 hexane/EtOAc). The reaction was concentrated, azeotroped with toluene and taken on without further purification.
후처리
- customthe resulting reaction
- temperaturemaintained for 30 min
- concentrationThe reaction was concentrated
- customazeotroped with toluene
- customtaken on without further purification
출처 및 근거
- ORD 기록
- ord-b272333b6f17485f927833b273755ad7
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07728010B2
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