Hydrochloric Acid → Ethyl 3-amino-3-phenylpropanoate

HRID 1353036

반응식

HRID 1353036 반응식
[NH2:1][C@H:2]([CH2:9][C:10]([OH:12])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl.[CH2:14](O)[CH3:15]>>[NH2:1][CH:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[CH2:9][C:10]([O:12][CH2:14][CH3:15])=[O:11]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 686703(3R)-3-amino-3-phenylpropanoic acid

생성물 1

HCID 236379Ethyl 3-amino-3-phenylpropanoate

실험 절차

β-Phenylalanine from II.2a (93) was suspended in ethanol (1.5 l) and the solution was saturated with gaseous HCl at room temperature. It was then heated under reflux for 4 h and stirred overnight at room temperature. The solution was cooled to 5° C. and filtered with suction. The filtrate was concentrated in vacuo, and the residue was washed with ether and dried. A white solid was obtained (yield: 52 g).

후처리

  1. temperatureIt was then heated
  2. temperatureunder reflux for 4 h
  3. temperatureThe solution was cooled to 5° C.
  4. filtrationfiltered with suction
  5. concentrationThe filtrate was concentrated in vacuo
  6. washthe residue was washed with ether
  7. customdried
  8. customA white solid was obtained (yield: 52 g)

출처 및 근거

ORD 기록
ord-0ca7caf733524f749acffc30ae2cc99b
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220824B1

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