Methyl iodide → HCID 11271869, 화합물

HRID 1353084노트

반응식

HRID 1353084 반응식
C[O:2][C:3]([C:5]1[S:6][C:7]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:8][C:9]=1[NH:10][C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][N:23]2[CH2:27][CH2:26][CH2:25][CH2:24]2)=[C:16]([O:28][CH3:29])[CH:15]=1)=[S:12])=O.[C:36](=O)([O-])[O-].[K+].[K+].CI>CN(C=O)C>[CH3:29][O:28][C:16]1[CH:15]=[C:14]([N:13]2[C:3](=[O:2])[C:5]3[S:6][C:7]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[CH:8][C:9]=3[N:10]=[C:11]2[S:12][CH3:36])[CH:19]=[CH:18][C:17]=1[O:20][CH2:21][CH2:22][N:23]1[CH2:24][CH2:25][CH2:26][CH2:27]1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 11214411HCID 11214411, 화합물

생성물 1

HCID 11271869HCID 11271869, 화합물수율 50%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

This ester (300 mg, 0.56 mmol) and potassium carbonate (162 mg, 1.17 mmol) were suspended in dry DMF (5 ml) and treated with a solution of methyl iodide (83 mg, 0.59 mmol) in DMF (1 ml). When the addition was complete, the mixture was evaporated. The residue was purified by chromatography on silica gel (eluting with dichloromethane-methanol) giving the title compound in 50% yield;

후처리

  1. additionWhen the addition
  2. customthe mixture was evaporated
  3. customThe residue was purified by chromatography on silica gel (eluting with dichloromethane-methanol)

출처 및 근거

ORD 기록
ord-b55445fd8de5432b9586c1601ace5fe7
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220777B2

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