Pyrrolidine → 3-(2-Hydroxy-4-nitrophenyl)-1-pyrrolidin-1-yl-propan-1-one

HRID 1353086노트

반응식

HRID 1353086 반응식
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][C:10](=[O:14])[O:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>O1CCCC1>[OH:11][C:12]1[CH:13]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][C:7]=1[CH2:8][CH2:9][C:10]([N:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1)=[O:14]

참가 물질

4

반응물 2

HCID 31268PyrrolidineHCID 179893417-Nitro-chroman-2-one

생성물 1

HCID 179894043-(2-Hydroxy-4-nitrophenyl)-1-pyrrolidin-1-yl-propan-1-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The crude 7-nitro-chroman-2-one (1.1 g, approx. 4.2 mmol) was dissolved in tetrahydrofuran (15 ml). Pyrrolidine (0.35 ml) was added and the reaction mixture stirred for 1 hour. The solution was adsorbed onto silica and eluted using methanol in dichloromethane. 3-(2-hydroxy-4-nitrophenyl)-1-pyrrolidin-1-yl-propan-1-one was obtained as a brown solid (900 mg, 3.40 mmol);

후처리

  1. washeluted

출처 및 근거

ORD 기록
ord-b26261e7abc241b48ba15ed8de4115b1
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220777B2

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