N,N-Dimethylaniline → 2,6-Di(propan-2-yl)phenyl carbonochloridate

HRID 1353175

반응식

HRID 1353175 반응식
[C:1]([Cl:4])(Cl)=[O:2].[CH3:5][CH:6]([C:8]1[CH:9]=[CH:10][CH:11]=[C:12]([CH:15]([CH3:17])[CH3:16])[C:13]=1[OH:14])[CH3:7].CN(C)C1C=CC=CC=1>>[CH:15]([C:12]1[CH:11]=[CH:10][CH:9]=[C:8]([CH:6]([CH3:7])[CH3:5])[C:13]=1[O:14][C:1]([Cl:4])=[O:2])([CH3:17])[CH3:16]

참가 물질

4

반응물 3

HCID 949N,N-DimethylanilineHCID 4943PropofolHCID 6371Phosgene

생성물 1

HCID 2716192,6-Di(propan-2-yl)phenyl carbonochloridate

반응 조건

온도
0 °C

실험 절차

Phosgene (13 mL, 20% in toluene) was added to propofol (3.6 g, 20 mmol) under a nitrogen atmosphere. The mixture was cooled to 0° C. and N,N-dimethylaniline (3.3 mL, 26 mmol) was added dropwise. The reaction mixture was allowed to warm to room temperature slowly and stirred for 14 h. The solvent was removed in vacuo. The crude product was carried to next step without further purification.

후처리

  1. temperatureto warm to room temperature slowly
  2. customThe solvent was removed in vacuo
  3. customThe crude product was carried to next step without further purification

출처 및 근거

ORD 기록
ord-3a3bb6e61312458e836096027f049d39
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220875B2

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