Water → Ethyl (2-formamido-5-chlorothiazol-4-yl)glyoxylate

HRID 13532

반응식

HRID 13532 반응식
[CH:1]([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:8]=1)=[O:2].[Cl:16]N1C(=O)CCC1=O.O>CN(C=O)C>[CH:1]([NH:3][C:4]1[S:5][C:6]([Cl:16])=[C:7]([C:9](=[O:15])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:8]=1)=[O:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 2733245Ethyl 2-(formylamino)-alpha-oxo-4-thiazoleacetate

생성물 1

HCID 14326717Ethyl (2-formamido-5-chlorothiazol-4-yl)glyoxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Ethyl 2-(Formylaminothiazol-4-yl)-2-oxoacetate (9.1 g, 39.87 mmol) (obtained from Aldrich, Milwaukee, Wis.) was slurried in 50 mL of anhydrous DMF. N-Chlorosuccinimide (5.6 g, 41.86 mmol) was added as a solid and the suspension was stirred at room temperature. After 18 hours, the reaction mixture was poured into 500 mL of water. The resulting white precipitate was filtered, washed with water and air dried to afford the title intermediate as a white solid.

후처리

  1. filtrationThe resulting white precipitate was filtered
  2. washwashed with water and air
  3. customdried

출처 및 근거

ORD 기록
ord-572aaac4a1614a098cd42dd318d131d2
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728127B2

연결된 노트

불러오는 중…