Diisopropylethylamine → 4-(2-Amino-7-chloro-4-quinolinyl)-N-[(3S)-hexahydro-2-oxo-1H-azepin-3-yl]-1-piperazinecarboxamide

HRID 1353473

반응식

HRID 1353473 반응식
[NH2:1][C@H:2]1[CH2:8][CH2:7][CH2:6][CH2:5][NH:4][C:3]1=[O:9].Cl[C:11](OC1C=CC([N+]([O-])=O)=CC=1)=[O:12].C(N(C(C)C)CC)(C)C.[Cl:32][C:33]1[CH:42]=[C:41]2[C:36]([C:37]([N:44]3[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]3)=[CH:38][C:39]([NH2:43])=[N:40]2)=[CH:35][CH:34]=1>>[NH2:43][C:39]1[CH:38]=[C:37]([N:44]2[CH2:49][CH2:48][N:47]([C:11]([NH:1][C@H:2]3[CH2:8][CH2:7][CH2:6][CH2:5][NH:4][C:3]3=[O:9])=[O:12])[CH2:46][CH2:45]2)[C:36]2[C:41](=[CH:42][C:33]([Cl:32])=[CH:34][CH:35]=2)[N:40]=1

참가 물질

5

반응물 4

HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 440599L-2-aminohexano-6-lactamHCID 211017487-Chloro-4-(1-piperazinyl)-2-quinolinamine

생성물 1

HCID 98666414-(2-Amino-7-chloro-4-quinolinyl)-N-[(3S)-hexahydro-2-oxo-1H-azepin-3-yl]-1-piperazinecarboxamide

실험 절차

As described for example 78, (s)-3-amino-azepan-2-one, 4-nitrophenyl chloroformate, diisopropyl(ethyl)amine, and 7-chloro-4-(1-piperazinyl)-2-quinolinamine are reacted to afford the product as a light yellow solid. LC-MS: 417 (M++1). 1H NMR (CD3OD) δ 7.80 (d, 1H), 7.45 (s, 1H), 7.15 (d, 1H), 6.35 (s, 1H), 4.45 (d, 1H), 3.68 (m, 4H), 3.25 (m, 2H), 3.10 (m, 4H), 2.00 (m, 2H), 1.80 (m, 2H), 1.60 (m, 1H), 1.38 (m, 1H).

후처리

  1. customare reacted

출처 및 근거

ORD 기록
ord-8799d199597f414996da651a01704d7f
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07220856B2

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