8-(6-Methoxy-[1,5]naphthyridin-4-ylethynyl)-1,4-dioxa-spiro[4.5]decan-8-ol → 8-[2-(6-Methoxy-[1,5]naphthyridin-4-yl)ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol

HRID 1354212노트

반응식

HRID 1354212 반응식
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[C:13]#[C:14][C:15]1([OH:25])[CH2:24][CH2:23][C:18]2([O:22][CH2:21][CH2:20][O:19]2)[CH2:17][CH2:16]1.[H][H]>C(O)C.O=[Pt]=O>[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[CH2:13][CH2:14][C:15]1([OH:25])[CH2:16][CH2:17][C:18]2([O:22][CH2:21][CH2:20][O:19]2)[CH2:23][CH2:24]1

참가 물질

5

반응물 2

HCID 211046678-(6-Methoxy-[1,5]naphthyridin-4-ylethynyl)-1,4-dioxa-spiro[4.5]decan-8-olHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 211046648-[2-(6-Methoxy-[1,5]naphthyridin-4-yl)ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매

실험 절차

A solution of 8-(6-methoxy-[1,5]naphthyridin-4-ylethynyl)-1,4-dioxa-spiro[4.5]decan-8-ol (965 mg, 2.8 mmol) in ethanol (100 ml) was hydrogenated for 6 hours over PtO2 (200 mg) at 1 bar of hydrogen. The catalyst was filtered off and replaced by fresh catalyst and the hydrogenation was continued for a further 3 hours. The catalyst was filtered off and the solvent was concentrated. The crude product was purified by chromatography on silica gel (EtOAc).

후처리

  1. filtrationThe catalyst was filtered off
  2. filtrationThe catalyst was filtered off
  3. concentrationthe solvent was concentrated
  4. customThe crude product was purified by chromatography on silica gel (EtOAc)

출처 및 근거

ORD 기록
ord-1c93d1b9bbd54b3ba19702f2923804ce
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223776B2

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