Sodium borohydride → Tert-butyl 2-hydroxy-2-(pyridin-3-yl)ethylcarbamate

HRID 1354403노트

반응식

HRID 1354403 반응식
[O:1]=[C:2]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].[BH4-].[Na+]>C(O)C>[OH:1][CH:2]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH2:3][NH:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 58993194tert-Butyl (2-oxo-2-(pyridin-3-yl)ethyl)carbamate

생성물 1

HCID 19351381Tert-butyl 2-hydroxy-2-(pyridin-3-yl)ethylcarbamate수율 103%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of the product from step (b) (1.30 g) in ethanol (50 ml) was added sodium borohydride (105 mg). The mixture was stirred for 1.5 h then evaporated. Water was added and the mixture extracted twice with ethyl acetate. The combined organic layers were washed (brine) and dried (MgSO4). The solvent was evaporated off to give the sub-title compound (1.35 g) as an oil.

후처리

  1. customthen evaporated
  2. additionWater was added
  3. extractionthe mixture extracted twice with ethyl acetate
  4. washThe combined organic layers were washed (brine)
  5. dry with materialdried (MgSO4)
  6. customThe solvent was evaporated off

출처 및 근거

ORD 기록
ord-822bfe8892a74c148d6c5ff5b093b398
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223794B2

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