Stannous Chloride → HCID 146733, 화합물

HRID 1354567노트

반응식

HRID 1354567 반응식
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([CH:8]=[CH:9][C:10]2[C:11]3[C:16]([N:17]=[C:18]4[C:23]=2[CH:22]=[CH:21][CH:20]=[CH:19]4)=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:6][CH:5]=1)([O-])=O.[Sn](Cl)Cl>C(OCC)(=O)C.C(O)C>[NH2:1][C:4]1[CH:25]=[CH:24][C:7]([CH:8]=[CH:9][C:10]2[C:23]3[C:18]([N:17]=[C:16]4[C:11]=2[CH:12]=[CH:13][CH:14]=[CH:15]4)=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:6][CH:5]=1

참가 물질

5

반응물 2

HCID 24479Stannous ChlorideHCID 730989559-(4-Nitrostyryl)acridine2회

생성물 1

HCID 146733HCID 146733, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

The 9-(4-nitrostyryl)acridine product (2.86 g, 10.0 mmol) is dissolved in ethyl acetate (250 ml) and then brought to reflux. A solution of tin(II) chloride dehydrate (9.0 g, 40 mmol) in hot ethanol (150 ml) is cooled and added to the solution of 9-(4-nitrostyryl)acridine. The mixture is reacted under reflux and with stirring for 5 hours. After cooling, the 9-(4-aminostyryl)acridine precipitates and is isolated by filtration under vacuum. The filtrate is dried by evaporation and taken up in water (500 ml) with stirring. The solution is basified (pH 13–14) with a sodium hydroxide solution. The 9-(4-aminostyryl)acridine fraction previously isolated, which contains a high proportion of tin salt, is also basified. The 9-(4-aminostyryl)acridine is separated by filtration, washed with water and dried. It is sufficiently pure for the following step.

후처리

  1. temperatureto reflux
  2. customThe mixture is reacted
  3. temperatureunder reflux
  4. temperatureAfter cooling
  5. customthe 9-(4-aminostyryl)acridine precipitates
  6. customis isolated by filtration under vacuum
  7. customThe filtrate is dried by evaporation
  8. stirringwith stirring

출처 및 근거

ORD 기록
ord-5699240b52254bce8e67decfb3b46acb
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223865B2

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