Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1354607생성일: 2026년 10월 24일
1,4-Dioxane hydrochloride → 2-(4-Chloro-2-oxo-1,2-dihydro-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile
https://huagongshe.com/ko/reaction/1354607
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 반응물 | 2-(4-Iodo-2-methoxy-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile | HCID 22021013 | — |
| 생성물 | 2-(4-Chloro-2-oxo-1,2-dihydro-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile | HCID 135681642 | — |
반응 단계
A suspension of 2-(4-iodo-2-methoxy-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile (1.8 g, 4.63 mmol) in 4 M HCl dioxane (40 mL) was heated to 80° C. for 6 h and cooled to room temperature. The precipitate was filtered and dried. The crude product (1.08 g, 82%) was used for the next step without purification. LRMS (neg. ESI, (M−H)−) m/z 283.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07223757B2 |
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| 출처 데이터셋 | uspto-grants-2007_05 |
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| ORD ID | ord-1e4f7bb0be984132832467b73edb6a6c |
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| 출처 메모 | uspto-grants-2007_05 |
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