Acetone → HCID 86594881, 화합물

HRID 1354758

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH2:11][C@H:10]([CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:9]2)=[C:4]([F:22])[CH:3]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[CH3:36][C:37]([CH3:39])=O>>[F:22][C:4]1[CH:3]=[C:2]([NH:1][CH:37]([CH3:39])[CH3:36])[CH:7]=[CH:6][C:5]=1[N:8]1[CH2:12][CH2:11][C@H:10]([CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH2:9]1

참가 물질

반응물 3

HCID 180Acetone

HCID 2724942Triacetoxyborohydride

HCID 68988249tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamate

생성물 1

HCID 86594881HCID 86594881, 화합물

실험 절차

tert-Butyl (R)-[1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamate was alkylated with acetone using triacetoxyborohydride as reducing agent by method N. This resulted in the product with the molecular weight of 351.47 (C19H30FN3O2); MS (ESI): 352 (M+H+).

후처리

customThis resulted in the product with the molecular weight of 351.47 (C19H30FN3O2)

출처 및 근거

ORD 기록: ord-2cd95b45e15e4e1387e3f728178a8533
출처 데이터셋: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07223788B2

연결된 노트

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