Acetic Anhydride → 4-(3-Acetylaminophenyl)benzoic acid

HRID 1354779노트

반응식

HRID 1354779 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>N1C=CC=CC=1>[C:17]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1)(=[O:19])[CH3:18]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 27563554-(3-aminophenyl)benzoic Acid

생성물 1

HCID 200999844-(3-Acetylaminophenyl)benzoic acid

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

3′-Aminobiphenyl-4-carboxylic acid (0.2 g) was mixed with pyridine (0.7 g) and acetic anhydride (180 mg) and, after 14 hours, volatile fractions were removed. The residue was taken up in sodium hydroxide solution (2N) and washed with diethyl ether. The aqueous phase was acidified with hydrochloric acid and extracted with ethyl acetate. The organic phase was dried over magnesium sulfate and concentrated. This resulted in the product with the molecular weight of 255.28 (C15H13NO3); MS (ESI): 256 (M+H+).

후처리

  1. customvolatile fractions were removed
  2. washwashed with diethyl ether
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic phase was dried over magnesium sulfate
  5. concentrationconcentrated
  6. customThis resulted in the product with the molecular weight of 255.28 (C15H13NO3)

출처 및 근거

ORD 기록
ord-738835121b694eaeb42c5a3d3427156e
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223788B2

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