Water → 4-(1-Propoxyethyl)benzoic acid

HRID 1354794

반응식

HRID 1354794 반응식
[OH:1][CH:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10]C)=[O:9])=[CH:6][CH:5]=1)[CH3:3].[CH2:14](I)[CH2:15][CH3:16].[H-].[Na+].O>CN(C=O)C>[CH2:14]([O:1][CH:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)[CH3:3])[CH2:15][CH3:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 586417Methyl 4-(1-hydroxyethyl)benzoate

생성물 1

HCID 144734334-(1-Propoxyethyl)benzoic acid

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Methyl 4-(1-hydroxyethyl)benzoate (2.0 g) dissolved in DMF (30 ml) was mixed with propyl iodide (3.8 g), and then sodium hydride (50% in oil, 0.53 g) was added. After the end of the exothermic reaction, the mixture was stirred for 1 hour and then water was cautiously added. It was extracted with ethyl acetate, and the organic phase was dried over sodium sulfate, filtered and concentrated. The residue was hydrolyzed by method P-a. This resulted in the product with the molecular weight of 208.26 (C12H16O3); MS (ESI): 209 (M+H+).

후처리

  1. customAfter the end of the exothermic reaction
  2. extractionIt was extracted with ethyl acetate
  3. dry with materialthe organic phase was dried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customThis resulted in the product with the molecular weight of 208.26 (C12H16O3)

출처 및 근거

ORD 기록
ord-26726afcdd094cd9880a8a290125792b
출처 데이터셋
uspto-grants-2007_05
특허 번호
US07223788B2

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