4-Hydroxybenzaldehyde → HCID 157607, 화합물
반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[NH:10]1[CH2:16][C:14](=[O:15])[NH:13][C:11]1=[O:12].N1CCCCC1.Cl>O>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[C:16]2[NH:10][C:11](=[O:12])[NH:13][C:14]2=[O:15])=[CH:4][CH:3]=1참가 물질
6
반응 조건
- 온도
- 130 °C
실험 절차
A mixture of 4-hydroxybenzaldehyde (100 g, 0.819 M), hydantoin (90 g, 0.9 M) and piperidine (165 ml) was heated to 130° C. for 1 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was cooled to 60° C. and 3.21 water was added. The reaction mixture was acidified with 12N HCl. The precipitated solid was filtered and washed with cold water to yield the title compound of the formula (18) (147 g, 88%), (Org. Syn. Vol. V., pp627).
후처리
- customAfter completion of the reaction
- temperaturethe reaction mixture was cooled to 60° C.
- filtrationThe precipitated solid was filtered
- washwashed with cold water
출처 및 근거
- ORD 기록
- ord-659085e64d1a48429e9482e3b19c42e1
- 출처 데이터셋
- uspto-grants-2007_05
- 특허 번호
- US07223881B2
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